Stability of conditioned pain modulation in two musculoskeletal pain models: investigating the influence of shoulder pain intensity and gender.

Published online

Journal Article

BACKGROUND: Several chronic pain populations have demonstrated decreased conditioned pain modulation (CPM). However there is still a need to investigate the stability of CPM paradigms before the measure can be recommended for implementation. The purpose of the present study was to assess whether shoulder pain intensity and gender influence CPM stability within and between sessions. METHODS: This study examined two different musculoskeletal pain models, clinical shoulder pain and an experimental model of shoulder pain induced with eccentric exercise in healthy participants. Patients in the clinical cohort (N = 134) were tested before surgery and reassessed 3 months post-surgery. The healthy cohort (N = 190) was examined before inducing pain at the shoulder, and 48 and 96 hours later. RESULTS: Our results provide evidence that 1) stability of inhibition is not related to changes in pain intensity, and 2) there are sex differences for CPM stability within and between days. CONCLUSIONS: Fluctuation of pain intensity did not significantly influence CPM stability. Overall, the more stable situations for CPM were females from the clinical cohort and males from the healthy cohort.

Full Text

Duke Authors

Cited Authors

  • Valencia, C; Kindler, LL; Fillingim, RB; George, SZ

Published Date

  • June 10, 2013

Published In

Volume / Issue

  • 14 /

Start / End Page

  • 182 -

PubMed ID

  • 23758907

Pubmed Central ID

  • 23758907

Electronic International Standard Serial Number (EISSN)

  • 1471-2474

Digital Object Identifier (DOI)

  • 10.1186/1471-2474-14-182


  • eng

Conference Location

  • England