DOMINE: a comprehensive collection of known and predicted domain-domain interactions.


Journal Article

DOMINE is a comprehensive collection of known and predicted domain-domain interactions (DDIs) compiled from 15 different sources. The updated DOMINE includes 2285 new domain-domain interactions (DDIs) inferred from experimentally characterized high-resolution three-dimensional structures, and about 3500 novel predictions by five computational approaches published over the last 3 years. These additions bring the total number of unique DDIs in the updated version to 26,219 among 5140 unique Pfam domains, a 23% increase compared to 20,513 unique DDIs among 4346 unique domains in the previous version. The updated version now contains 6634 known DDIs, and features a new classification scheme to assign confidence levels to predicted DDIs. DOMINE will serve as a valuable resource to those studying protein and domain interactions. Most importantly, DOMINE will not only serve as an excellent reference to bench scientists testing for new interactions but also to bioinformaticans seeking to predict novel protein-protein interactions based on the DDIs. The contents of the DOMINE are available at

Full Text

Cited Authors

  • Yellaboina, S; Tasneem, A; Zaykin, DV; Raghavachari, B; Jothi, R

Published Date

  • January 2011

Published In

Volume / Issue

  • 39 / Database issue

Start / End Page

  • D730 - D735

PubMed ID

  • 21113022

Pubmed Central ID

  • 21113022

Electronic International Standard Serial Number (EISSN)

  • 1362-4962

Digital Object Identifier (DOI)

  • 10.1093/nar/gkq1229


  • eng

Conference Location

  • England