DOMINE: a database of protein domain interactions.


Journal Article

DOMINE is a database of known and predicted protein domain interactions compiled from a variety of sources. The database contains domain-domain interactions observed in PDB entries, and those that were predicted by eight different computational approaches. DOMINE contains a total of 20 513 unique domain-domain interactions among 4036 Pfam domains, out of which 4349 are inferred from PDB entries and 17 781 were predicted by at least one computational approach. This database will serve as a valuable resource to those working in the field of protein and domain interactions. DOMINE may not only serve as a reference to experimentalists who test for new protein and domain interactions, but also offers a consolidated dataset for analysis by bioinformaticians who seek to test ideas regarding the underlying factors that control the topological structure of interaction networks. DOMINE is freely available at

Full Text

Cited Authors

  • Raghavachari, B; Tasneem, A; Przytycka, TM; Jothi, R

Published Date

  • January 2008

Published In

Volume / Issue

  • 36 / Database issue

Start / End Page

  • D656 - D661

PubMed ID

  • 17913741

Pubmed Central ID

  • 17913741

Electronic International Standard Serial Number (EISSN)

  • 1362-4962

Digital Object Identifier (DOI)

  • 10.1093/nar/gkm761


  • eng

Conference Location

  • England