Use of p-aminobenzoic acid to monitor compliance with prescribed dietary regimens during metabolic balance studies in man.

Journal Article

A new method is described for simultaneously monitoring compliance with prescribed-diet and urine-collection regimens during metabolic balance studies. It involves incorporation of the potassium salt of p-aminobenzoic acid (PABA) into provided foods and measurement of its extent of recovery in urine. A validation study was conducted in 10 healthy adults. During three consecutive 24-h periods, subjects consumed four foods per day that had each been supplemented with 72.0 mg PABA and also made complete urine collections. An additional 24-h urine collection was made by each subject for determination of baseline PABA excretion. The PABA was easily incorporated into the test foods and was not detected by taste. The recovery of the PABA in urine, determined by colorimetric assay, was 98.7 +/- 3.7% (means +/- SD) of intake. Thus, in metabolic studies for greater than or equal to 3 d, PABA can be used to provide a sensitive index of dietary compliance.

Full Text

Duke Authors

Cited Authors

  • Roberts, SB; Morrow, FD; Evans, WJ; Shepard, DC; Dallal, GE; Meredith, CN; Young, VR

Published Date

  • March 1, 1990

Published In

Volume / Issue

  • 51 / 3

Start / End Page

  • 485 - 488

PubMed ID

  • 2309655

Electronic International Standard Serial Number (EISSN)

  • 1938-3207

International Standard Serial Number (ISSN)

  • 0002-9165

Digital Object Identifier (DOI)

  • 10.1093/ajcn/51.3.485

Language

  • eng