The etiology and reversibility of muscle dysfunction in the aged.

Journal Article (Journal Article;Review)

Muscle weakness in the elderly is prevalent and morbid, closely linked to the frailty, functional decline, immobility, falls, and injuries in this population. The marked decrease in skeletal muscle strength and size with aging is a multifactorial syndrome which may be attributable in part to: (a) biological changes of aging itself; (b) the accumulation of acute and chronic diseases; (c) the assumption of a sedentary life style, and (d) selective or generalized nutritional inadequacies. Inactivity and undernutrition are potentially at least partially reversible with appropriate interventions, and therefore the delineation of the attributable risk of these two factors to the muscle weakness of aging is a critical research goal. Similarly, identification of appropriate modalities of physical activity and nutrition which have positive effects on muscle physiology in the aged is the focus of major investigations currently.

Full Text

Duke Authors

Cited Authors

  • Fiatarone, MA; Evans, WJ

Published Date

  • September 1993

Published In

Volume / Issue

  • 48 Spec No /

Start / End Page

  • 77 - 83

PubMed ID

  • 8409245

International Standard Serial Number (ISSN)

  • 0022-1422

Digital Object Identifier (DOI)

  • 10.1093/geronj/48.special_issue.77


  • eng

Conference Location

  • United States