Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.

Published

Journal Article

Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form ribonucleoproteins to guide covalent modifications of ribosomal and small nuclear RNAs in the nucleus. Recent studies have also uncovered additional non-canonical roles for snoRNAs. However, the physiological contributions of these small RNAs are largely unknown. Here, we selectively deleted four snoRNAs encoded within the introns of the ribosomal protein L13a (Rpl13a) locus in a mouse model. Loss of Rpl13a snoRNAs altered mitochondrial metabolism and lowered reactive oxygen species tone, leading to increased glucose-stimulated insulin secretion from pancreatic islets and enhanced systemic glucose tolerance. Islets from mice lacking Rpl13a snoRNAs demonstrated blunted oxidative stress responses. Furthermore, these mice were protected against diabetogenic stimuli that cause oxidative stress damage to islets. Our study illuminates a previously unrecognized role for snoRNAs in metabolic regulation.

Full Text

Duke Authors

Cited Authors

  • Lee, J; Harris, AN; Holley, CL; Mahadevan, J; Pyles, KD; Lavagnino, Z; Scherrer, DE; Fujiwara, H; Sidhu, R; Zhang, J; Huang, SC-C; Piston, DW; Remedi, MS; Urano, F; Ory, DS; Schaffer, JE

Published Date

  • December 2016

Published In

Volume / Issue

  • 126 / 12

Start / End Page

  • 4616 - 4625

PubMed ID

  • 27820699

Pubmed Central ID

  • 27820699

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI88069

Language

  • eng