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Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications.

Publication ,  Journal Article
Kim, JH; Shah, P; Tantry, US; Gurbel, PA
Published in: Curr Heart Fail Rep
December 2016

Heart failure (HF) represents a heterogeneous condition characterized by vulnerabilities in the blood, vasculature, and impaired flow dynamics that predispose to both arterial and venous thrombosis. Despite evidence-based advances in the medical and device management of chronic HF, it remains a leading cause of morbidity and mortality in the USA due to repeat hospitalizations and comorbid conditions such as atrial fibrillation (AF) and stroke. The presence of platelet activation and hypercoagulability in HF has been well documented. Anticoagulation is effective in HF when comorbidities such as AF and prior venous thromboembolism exist. However, data is less clear for HF in sinus rhythm. Moreover, there is a paucity of data regarding antiplatelet therapy in HF. No consensus guidelines exist regarding the precise role of antiplatelet or antithrombotic therapy in HF. This review addresses the pathophysiology of coagulation abnormalities in HF, examines the available evidence regarding the use of anticoagulants and antiplatelet agents in HF, and discusses its therapeutic implications.

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Published In

Curr Heart Fail Rep

DOI

EISSN

1546-9549

Publication Date

December 2016

Volume

13

Issue

6

Start / End Page

319 / 328

Location

United States

Related Subject Headings

  • Thromboembolism
  • Stroke
  • Platelet Aggregation Inhibitors
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Blood Coagulation Disorders
  • Atrial Fibrillation
  • Anticoagulants
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Kim, J. H., Shah, P., Tantry, U. S., & Gurbel, P. A. (2016). Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications. Curr Heart Fail Rep, 13(6), 319–328. https://doi.org/10.1007/s11897-016-0308-6
Kim, Ju H., Palak Shah, Udaya S. Tantry, and Paul A. Gurbel. “Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications.Curr Heart Fail Rep 13, no. 6 (December 2016): 319–28. https://doi.org/10.1007/s11897-016-0308-6.
Kim JH, Shah P, Tantry US, Gurbel PA. Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications. Curr Heart Fail Rep. 2016 Dec;13(6):319–28.
Kim, Ju H., et al. “Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications.Curr Heart Fail Rep, vol. 13, no. 6, Dec. 2016, pp. 319–28. Pubmed, doi:10.1007/s11897-016-0308-6.
Kim JH, Shah P, Tantry US, Gurbel PA. Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications. Curr Heart Fail Rep. 2016 Dec;13(6):319–328.
Journal cover image

Published In

Curr Heart Fail Rep

DOI

EISSN

1546-9549

Publication Date

December 2016

Volume

13

Issue

6

Start / End Page

319 / 328

Location

United States

Related Subject Headings

  • Thromboembolism
  • Stroke
  • Platelet Aggregation Inhibitors
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Blood Coagulation Disorders
  • Atrial Fibrillation
  • Anticoagulants
  • 3201 Cardiovascular medicine and haematology