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Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma

Publication ,  Journal Article
Ludmir, EB; Palta, M; Zhang, X; Wu, Y; Willett, CG; Czito, BG
Published in: Journal of Gastrointestinal Oncology
January 1, 2014

Background: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. This study retrospectively analyzes both outcomes of CEC patients treated with CRT and the incidence and potential role of HPV tumor infection in CEC lesions. Methods: A total of 37 CEC patients were treated with definitive CRT at our institution between 1987 and 2013. Of these, 19 had tumor samples available for high-risk HPV (types 16 and 18) pathological analysis. Results: For all patients (n=37), 5-year overall survival (OS), disease-free survival (DFS), and loco-regional control (LRC) rates were 34.1%, 40.2%, and 65.6%, respectively. On pathological analysis, 1/19 (5.3%) patients had an HPV-positive lesion. Conclusions: Definitive CRT provides disease-related outcomes comparable to surgery. Moreover, HPV tumor infection in CEC is uncommon and its prognostic role is unclear. Our data contribute to the construction of an anatomical map of HPV tumor infection in squamous cell carcinomas (SCC) of the upper aerodigestive tract, and suggest a steep drop in viral infection rates at sites distal to the oropharynx, including the cervical esophagus.

Duke Scholars

Published In

Journal of Gastrointestinal Oncology

DOI

EISSN

2219-679X

ISSN

2078-6891

Publication Date

January 1, 2014

Volume

5

Issue

6

Start / End Page

401 / 407

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ludmir, E. B., Palta, M., Zhang, X., Wu, Y., Willett, C. G., & Czito, B. G. (2014). Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma. Journal of Gastrointestinal Oncology, 5(6), 401–407. https://doi.org/10.3978/j.issn.2078-6891.2014.05
Ludmir, E. B., M. Palta, X. Zhang, Y. Wu, C. G. Willett, and B. G. Czito. “Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.” Journal of Gastrointestinal Oncology 5, no. 6 (January 1, 2014): 401–7. https://doi.org/10.3978/j.issn.2078-6891.2014.05.
Ludmir EB, Palta M, Zhang X, Wu Y, Willett CG, Czito BG. Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma. Journal of Gastrointestinal Oncology. 2014 Jan 1;5(6):401–7.
Ludmir, E. B., et al. “Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.” Journal of Gastrointestinal Oncology, vol. 5, no. 6, Jan. 2014, pp. 401–07. Scopus, doi:10.3978/j.issn.2078-6891.2014.05.
Ludmir EB, Palta M, Zhang X, Wu Y, Willett CG, Czito BG. Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma. Journal of Gastrointestinal Oncology. 2014 Jan 1;5(6):401–407.

Published In

Journal of Gastrointestinal Oncology

DOI

EISSN

2219-679X

ISSN

2078-6891

Publication Date

January 1, 2014

Volume

5

Issue

6

Start / End Page

401 / 407

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences