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The pathobiology of vascular malformations: insights from human and model organism genetics.

Publication ,  Journal Article
Wetzel-Strong, SE; Detter, MR; Marchuk, DA
Published in: J Pathol
January 2017

Vascular malformations may arise in any of the vascular beds present in the human body. These lesions vary in location, type, and clinical severity of the phenotype. In recent years, the genetic basis of several vascular malformations has been elucidated. This review will consider how the identification of the genetic factors contributing to different vascular malformations, with subsequent functional studies in animal models, has provided a better understanding of these factors that maintain vascular integrity in vascular beds, as well as their role in the pathogenesis of vascular malformations. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

January 2017

Volume

241

Issue

2

Start / End Page

281 / 293

Location

England

Related Subject Headings

  • Vascular Malformations
  • Transforming Growth Factor beta2
  • Pathology
  • Organisms, Genetically Modified
  • Models, Animal
  • Humans
  • Genetic Predisposition to Disease
  • Endothelial Cells
  • Animals
  • 3211 Oncology and carcinogenesis
 

Citation

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Wetzel-Strong, S. E., Detter, M. R., & Marchuk, D. A. (2017). The pathobiology of vascular malformations: insights from human and model organism genetics. J Pathol, 241(2), 281–293. https://doi.org/10.1002/path.4844
Wetzel-Strong, Sarah E., Matthew R. Detter, and Douglas A. Marchuk. “The pathobiology of vascular malformations: insights from human and model organism genetics.J Pathol 241, no. 2 (January 2017): 281–93. https://doi.org/10.1002/path.4844.
Wetzel-Strong SE, Detter MR, Marchuk DA. The pathobiology of vascular malformations: insights from human and model organism genetics. J Pathol. 2017 Jan;241(2):281–93.
Wetzel-Strong, Sarah E., et al. “The pathobiology of vascular malformations: insights from human and model organism genetics.J Pathol, vol. 241, no. 2, Jan. 2017, pp. 281–93. Pubmed, doi:10.1002/path.4844.
Wetzel-Strong SE, Detter MR, Marchuk DA. The pathobiology of vascular malformations: insights from human and model organism genetics. J Pathol. 2017 Jan;241(2):281–293.
Journal cover image

Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

January 2017

Volume

241

Issue

2

Start / End Page

281 / 293

Location

England

Related Subject Headings

  • Vascular Malformations
  • Transforming Growth Factor beta2
  • Pathology
  • Organisms, Genetically Modified
  • Models, Animal
  • Humans
  • Genetic Predisposition to Disease
  • Endothelial Cells
  • Animals
  • 3211 Oncology and carcinogenesis