Diacylglycerol Kinases in T Cell Tolerance and Effector Function.

Published online

Journal Article (Review)

Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and PA are important second messengers cascading T cell receptor (TCR) signal by recruiting multiple effector molecules, such as RasGRP1, PKCθ, and mTOR. Studies have revealed important physiological functions of DGKs in the regulation of receptor signaling and the development and activation of immune cells. In this review, we will focus on recent progresses in our understanding of two DGK isoforms, α and ζ, in CD8 T effector and memory cell differentiation, regulatory T cell development and function, and invariant NKT cell development and effector lineage differentiation.

Full Text

Duke Authors

Cited Authors

  • Chen, SS; Hu, Z; Zhong, X-P

Published Date

  • 2016

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 130 -

PubMed ID

  • 27891502

Pubmed Central ID

  • 27891502

International Standard Serial Number (ISSN)

  • 2296-634X

Digital Object Identifier (DOI)

  • 10.3389/fcell.2016.00130

Language

  • eng

Conference Location

  • Switzerland