Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing.
Journal Article (Journal Article)
OBJECTIVE: The aim of this study was to identify risk factors for early-onset group B Streptococcus (EOGBS) disease in neonates of mothers with negative antenatal screening. STUDY DESIGN: We performed a retrospective cohort study of neonates born to mothers with negative antenatal GBS screening between 2002 and 2012. Our primary outcome was EOGBS infection. We used multivariable logistic regression to assess factors associated with EOGBS. RESULTS: EOGBS was confirmed in 492 of the 179 818 neonates that met the study inclusion criteria. Risk factors for EOGBS included black race (reference: white, odds ratio (OR) =1.81 (95% confidence interval: 1.43, 2.31)), maternal age <18 years (reference: >35 years, OR=2.63 (1.54, 4.51)) and maternal age 18 to 35 years (reference: >35 years, OR=1.94 (1.30, 2.88)). CONCLUSION: Maternal age <18 years and black race were the strongest predictors of EOGBS. Further research investigating contributors to the discordance between screening results and neonatal outcomes in these populations is needed.
Full Text
Duke Authors
- Benjamin Jr., Daniel Kelly
- Greenberg, Rachel Gottron
- Messina, Julia Antoinette
- Parente, Victoria Marie
- Perfect, John Robert
- Smith, Phillip Brian
Cited Authors
- Parente, V; Clark, RH; Ku, L; Fennell, C; Johnson, M; Morris, E; Romaine, A; Utin, U; Benjamin, DK; Messina, JA; Smith, PB; Greenberg, RG
Published Date
- February 2017
Published In
Volume / Issue
- 37 / 2
Start / End Page
- 157 - 161
PubMed ID
- 27853322
Pubmed Central ID
- PMC5280520
Electronic International Standard Serial Number (EISSN)
- 1476-5543
Digital Object Identifier (DOI)
- 10.1038/jp.2016.201
Language
- eng
Conference Location
- United States