Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
Journal Article (Journal Article)
Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We demonstrated further that Raptor/mTORC1 deficiency did not affect AMϕ development, but compromised its proliferative activity at cell cycle entry in the steady-state as well as in the context of repopulation in irradiation chimeras. Mechanically, mTORC1 confers AMϕ optimal responsiveness to GM-CSF-induced proliferation. Thus, our results demonstrate an essential role of mTORC1 for AMϕ homeostasis by regulating proliferative renewal.
Full Text
Duke Authors
Cited Authors
- Deng, W; Yang, J; Lin, X; Shin, J; Gao, J; Zhong, X-P
Published Date
- January 1, 2017
Published In
Volume / Issue
- 198 / 1
Start / End Page
- 492 - 504
PubMed ID
- 27881705
Pubmed Central ID
- PMC5173435
Electronic International Standard Serial Number (EISSN)
- 1550-6606
Digital Object Identifier (DOI)
- 10.4049/jimmunol.1501845
Language
- eng
Conference Location
- United States