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Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine.

Publication ,  Journal Article
McNearney, TA; Hunnicutt, SE; Fischbach, M; Friedman, AW; Aguilar, M; Ahn, CW; Reveille, JD; Lisse, JR; Baethge, BA; Goel, N; Mayes, MD ...
Published in: J Rheumatol
December 2009

OBJECTIVE: To measure self-reported physical and mental functioning and associated clinical features at study entry in 3 ethnic groups with systemic sclerosis (SSc). METHODS: Sixty Hispanic, 39 African American, and 104 Caucasian patients with recent-onset SSc (< 5 yrs) were assessed for perceived physical and mental functioning, using the Medical Outcomes Study Short Form-36 (SF-36) and Scleroderma-Health Assessment Questionnaire (Scleroderma-HAQ). Socioeconomic, demographic, clinical, immunologic, immunogenetic, behavioral, and psychological variables (Interpersonal Support Evaluation List, ISEL; Illness Behavior Questionnaire, IBQ; and Arthritis Helplessness Index, AHI) were analyzed by linear regression models for associations with SF-36 and mHAQ scores as dependent variables. RESULTS: Perceived physical functioning scores had ethnic-specific associations with AHI > fatigue scores > IBQ > clinical variables (hypertension, skin score, and percentage predicted DLCO). Scleroderma-HAQ scores had ethnic-specific associations with IBQ > AHI scores > most clinical and laboratory variables. Decreased mental component summary (MCS) scores associated with AHI > ISEL. Ethnic-specific immunogenetic variables HLA-DQB1*0202 (Caucasian) and HLA-DRB 1*11 (African American), and HLA-DQA1*0501 (Hispanic) also associated with MCS. Antinuclear autoantibodies, anti-topoisomerase I, and RNA polymerases I and III also demonstrated associations with functioning in African American and Hispanic groups. CONCLUSION: Clinical, psychosocial, and immunogenetic variables had ethnic-specific associations with perceived physical and mental functioning. Consideration of ethnic-specific psychological and behavioral support in designing more personalized, relevant therapeutic interventions for the patient may improve therapeutic efficacy in SSc.

Duke Scholars

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

December 2009

Volume

36

Issue

12

Start / End Page

2724 / 2732

Location

Canada

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Scleroderma, Systemic
  • Reproducibility of Results
  • Quality of Life
  • Precision Medicine
  • Humans
  • Hispanic or Latino
  • Health Behavior
  • HLA-DQ Antigens
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McNearney, T. A., Hunnicutt, S. E., Fischbach, M., Friedman, A. W., Aguilar, M., Ahn, C. W., … GENISOS Study Group, . (2009). Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine. J Rheumatol, 36(12), 2724–2732. https://doi.org/10.3899/jrheum.090295
McNearney, Terry A., Sonya E. Hunnicutt, Michael Fischbach, Alan W. Friedman, Martha Aguilar, Chul W. Ahn, John D. Reveille, et al. “Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine.J Rheumatol 36, no. 12 (December 2009): 2724–32. https://doi.org/10.3899/jrheum.090295.
McNearney TA, Hunnicutt SE, Fischbach M, Friedman AW, Aguilar M, Ahn CW, et al. Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine. J Rheumatol. 2009 Dec;36(12):2724–32.
McNearney, Terry A., et al. “Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine.J Rheumatol, vol. 36, no. 12, Dec. 2009, pp. 2724–32. Pubmed, doi:10.3899/jrheum.090295.
McNearney TA, Hunnicutt SE, Fischbach M, Friedman AW, Aguilar M, Ahn CW, Reveille JD, Lisse JR, Baethge BA, Goel N, Mayes MD, GENISOS Study Group. Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine. J Rheumatol. 2009 Dec;36(12):2724–2732.

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

December 2009

Volume

36

Issue

12

Start / End Page

2724 / 2732

Location

Canada

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Scleroderma, Systemic
  • Reproducibility of Results
  • Quality of Life
  • Precision Medicine
  • Humans
  • Hispanic or Latino
  • Health Behavior
  • HLA-DQ Antigens