Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer.

Journal Article (Journal Article)

The combination chemotherapy regimen of cisplatin (CP) and docetaxel (DTX) is effective against a variety of cancers. However, combination therapies present unique challenges that can complicate clinical application, such as increases in toxicity and imprecise exposure of tumors to specific drug ratios that can produce treatment resistance. Drug co-encapsulation within a single nanoparticle (NP) formulation can overcome these challenges and further improve combinations' therapeutic index. In this report, we employ a CP prodrug (CPP) strategy to formulate poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) NPs carrying both CPP and DTX. The dually loaded NPs display differences in drug release kinetics and in vitro cytotoxicity based on the structure of the chosen CPP. Furthermore, NPs containing both drugs showed a significant improvement in treatment efficacy versus the free drug combination in vivo.

Full Text

Duke Authors

Cited Authors

  • Tian, J; Min, Y; Rodgers, Z; Wan, X; Qiu, H; Mi, Y; Tian, X; Wagner, KT; Caster, JM; Qi, Y; Roche, K; Zhang, T; Cheng, J; Wang, AZ

Published Date

  • April 2017

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 1301 - 1307

PubMed ID

  • 27884641

Pubmed Central ID

  • PMC5392447

Electronic International Standard Serial Number (EISSN)

  • 1549-9642

Digital Object Identifier (DOI)

  • 10.1016/j.nano.2016.11.007


  • eng

Conference Location

  • United States