Skip to main content
Journal cover image

The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.

Publication ,  Journal Article
Witkowski, L; Donini, N; Byler-Dann, R; Knost, JA; Albrecht, S; Berchuck, A; McCluggage, WG; Hasselblatt, M; Foulkes, WD
Published in: Fam Cancer
July 2017

Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have stressed its morphological and clinical similarity to malignant rhabdoid tumours, which are usually caused by mutations in the related gene, SMARCB1. While familial tumours are rare, the incidence of germline mutations is relatively high, with up to 43% of SCCOHTs and 35% of rhabdoid tumours caused by germline mutations in SMARCA4 and SMARCB1, respectively. We report two new familial cases of SCCOHT. Affected members in both families and the associated tumours were found to carry SMARCA4 germline and somatic mutations, respectively, leading to loss of SMARCA4 protein expression in the tumours. Despite the rarity of familial SCCOHT, the high incidence of germline mutations is important to note, as without a family history of the disease, the hereditary nature of SCCOHT may be missed, especially if the mutation was inherited from the father or acquired de novo. The similarity between SCCOHT and rhabdoid tumours should be recognized, as infant carriers of SMARCA4 mutations may be at risk for these tumours in addition to SCCOHT.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Fam Cancer

DOI

EISSN

1573-7292

Publication Date

July 2017

Volume

16

Issue

3

Start / End Page

395 / 399

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Transcription Factors
  • Pedigree
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Mutation
  • Hypercalcemia
  • Humans
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Witkowski, L., Donini, N., Byler-Dann, R., Knost, J. A., Albrecht, S., Berchuck, A., … Foulkes, W. D. (2017). The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. Fam Cancer, 16(3), 395–399. https://doi.org/10.1007/s10689-016-9957-6
Witkowski, Leora, Nancy Donini, Rebecca Byler-Dann, James A. Knost, Steffen Albrecht, Andrew Berchuck, W Glenn McCluggage, Martin Hasselblatt, and William D. Foulkes. “The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.Fam Cancer 16, no. 3 (July 2017): 395–99. https://doi.org/10.1007/s10689-016-9957-6.
Witkowski L, Donini N, Byler-Dann R, Knost JA, Albrecht S, Berchuck A, et al. The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. Fam Cancer. 2017 Jul;16(3):395–9.
Witkowski, Leora, et al. “The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.Fam Cancer, vol. 16, no. 3, July 2017, pp. 395–99. Pubmed, doi:10.1007/s10689-016-9957-6.
Witkowski L, Donini N, Byler-Dann R, Knost JA, Albrecht S, Berchuck A, McCluggage WG, Hasselblatt M, Foulkes WD. The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. Fam Cancer. 2017 Jul;16(3):395–399.
Journal cover image

Published In

Fam Cancer

DOI

EISSN

1573-7292

Publication Date

July 2017

Volume

16

Issue

3

Start / End Page

395 / 399

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Transcription Factors
  • Pedigree
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Mutation
  • Hypercalcemia
  • Humans
  • Genetic Predisposition to Disease