Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

Conference Paper

Actin polymerization governs activity-dependent modulation of excitatory synapses, including their morphology and functionality. It is clear from human genetics that neuropsychiatric and neurodevelopmental disturbances are multigenetic in nature, highlighting the need to better understand the critical neural pathways associated with these disorders and how they are altered by genetic risk alleles. One such signaling pathway that is heavily implicated by candidate genes for psychiatric and neurodevelopmental disorders are regulators of signaling to the actin cytoskeleton, suggesting that its disruption and the ensuring abnormalities of spine structures and postsynaptic complexes is a commonly affected pathway in brain disorders. This review will discuss recent experimental findings that strongly support genetic evidence linking the synaptic cytoskeleton to mental disorders, such as schizophrenia and autism spectrum disorders.

Full Text

Duke Authors

Cited Authors

  • Yan, Z; Kim, E; Datta, D; Lewis, DA; Soderling, SH

Published Date

  • November 9, 2016

Published In

Volume / Issue

  • 36 / 45

Start / End Page

  • 11411 - 11417

PubMed ID

  • 27911743

Pubmed Central ID

  • PMC5125208

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.2360-16.2016

Conference Location

  • United States