Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.

Journal Article

Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.

Full Text

Duke Authors

Cited Authors

  • Liu, R-Y; Shah, S; Cleary, LJ; Byrne, JH

Published Date

  • January 2011

Published In

Volume / Issue

  • 18 / 4

Start / End Page

  • 245 - 249

PubMed ID

  • 21441301

Electronic International Standard Serial Number (EISSN)

  • 1549-5485

International Standard Serial Number (ISSN)

  • 1072-0502

Digital Object Identifier (DOI)

  • 10.1101/lm.2112111

Language

  • eng