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Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.

Publication ,  Journal Article
Liu, R-Y; Shah, S; Cleary, LJ; Byrne, JH
Published in: Learn Mem
2011

Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.

Duke Scholars

Published In

Learn Mem

DOI

EISSN

1549-5485

Publication Date

2011

Volume

18

Issue

4

Start / End Page

245 / 249

Location

United States

Related Subject Headings

  • Time Factors
  • Serotonin
  • Sensory Receptor Cells
  • Repressor Proteins
  • RNA, Messenger
  • Nonlinear Dynamics
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Gene Expression Regulation
  • Ganglia, Invertebrate
 

Citation

APA
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ICMJE
MLA
NLM
Liu, R.-Y., Shah, S., Cleary, L. J., & Byrne, J. H. (2011). Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. Learn Mem, 18(4), 245–249. https://doi.org/10.1101/lm.2112111
Liu, Rong-Yu, Shreyansh Shah, Leonard J. Cleary, and John H. Byrne. “Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.Learn Mem 18, no. 4 (2011): 245–49. https://doi.org/10.1101/lm.2112111.
Liu R-Y, Shah S, Cleary LJ, Byrne JH. Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. Learn Mem. 2011;18(4):245–9.
Liu, Rong-Yu, et al. “Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.Learn Mem, vol. 18, no. 4, 2011, pp. 245–49. Pubmed, doi:10.1101/lm.2112111.
Liu R-Y, Shah S, Cleary LJ, Byrne JH. Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. Learn Mem. 2011;18(4):245–249.

Published In

Learn Mem

DOI

EISSN

1549-5485

Publication Date

2011

Volume

18

Issue

4

Start / End Page

245 / 249

Location

United States

Related Subject Headings

  • Time Factors
  • Serotonin
  • Sensory Receptor Cells
  • Repressor Proteins
  • RNA, Messenger
  • Nonlinear Dynamics
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Gene Expression Regulation
  • Ganglia, Invertebrate