Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.


Journal Article

MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.

Full Text

Duke Authors

Cited Authors

  • Volk, N; Pape, JC; Engel, M; Zannas, AS; Cattane, N; Cattaneo, A; Binder, EB; Chen, A

Published Date

  • November 8, 2016

Published In

Volume / Issue

  • 17 / 7

Start / End Page

  • 1882 - 1891

PubMed ID

  • 27829158

Pubmed Central ID

  • 27829158

Electronic International Standard Serial Number (EISSN)

  • 2211-1247

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2016.10.038


  • eng

Conference Location

  • United States