Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.
Published
Journal Article
MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.
Full Text
Duke Authors
Cited Authors
- Volk, N; Pape, JC; Engel, M; Zannas, AS; Cattane, N; Cattaneo, A; Binder, EB; Chen, A
Published Date
- November 8, 2016
Published In
Volume / Issue
- 17 / 7
Start / End Page
- 1882 - 1891
PubMed ID
- 27829158
Pubmed Central ID
- 27829158
Electronic International Standard Serial Number (EISSN)
- 2211-1247
Digital Object Identifier (DOI)
- 10.1016/j.celrep.2016.10.038
Language
- eng
Conference Location
- United States