A prospective observational study of the effect of penicillin skin testing on antibiotic use in the intensive care unit.

Journal Article (Journal Article)

BACKGROUND: Patients with penicillin allergy admitted to the intensive care unit (ICU) frequently receive non-beta-lactam antimicrobials for the treatment of infection. The use of these antimicrobials, more commonly vancomycin and fluoroquinolones, is associated with the emergence of multidrug-resistant infections. The penicillin skin test (PST) can help detect patients at risk of developing an immediate allergic reaction to penicillin and those patients with a negative PST may be able to use a penicillin antibiotic safely. METHODS: We determined the incidence of true penicillin allergy, the percentage of patients changed to a beta-lactam antimicrobial when the test was negative, the safety of the test, and the safety of administration of beta-lactam antimicrobials in patients with a negative test. Skin testing was performed using standard methodology. RESULTS: One hundred patients admitted to 4 ICUs were prospectively studied; 58 of them were male. The mean age was 63 years. Ninety-six patients had the PST: one was positive (1.04%), 10 (10.4%) were nondiagnostic, and 85 (88.5%) were negative. Of the 38 patients who received antimicrobials for therapeutic reasons, 31(81.5%) had the antibiotic changed to a beta-lactam antimicrobial after a negative reading versus 7 patients of the 57 (12%) who had received a prophylactic antimicrobial (P < .001). No adverse effects were reported after the PST or after antimicrobial administration. CONCLUSIONS: The PST is a safe, reliable, and effective strategy to reduce the use of non-beta-lactam antimicrobials in patients who are labeled as penicillin allergic and admitted to the ICU.

Full Text

Duke Authors

Cited Authors

  • Arroliga, ME; Radojicic, C; Gordon, SM; Popovich, MJ; Bashour, CA; Melton, AL; Arroliga, AC

Published Date

  • May 2003

Published In

Volume / Issue

  • 24 / 5

Start / End Page

  • 347 - 350

PubMed ID

  • 12785408

International Standard Serial Number (ISSN)

  • 0899-823X

Digital Object Identifier (DOI)

  • 10.1086/502212


  • eng

Conference Location

  • United States