Titin and nebulin content in human skeletal muscle following eccentric resistance exercise.


Journal Article

We measured titin and nebulin content in muscle biopsies from the vastus lateralis before and 24 h after one bout of high-intensity eccentric knee extensor resistance exercise in seven men (26 +/- 3 years). Titin and nebulin content were significantly (P < 0.05) reduced after exercise by 30 and 15%, respectively. These results suggest that the structural components of the myofibrillar apparatus are degraded following high-intensity eccentric resistance exercise in humans. Loss of these proteins may have important implications for the mechanisms regulating the adaptive response of skeletal muscle to resistance exercise.

Full Text

Duke Authors

Cited Authors

  • Trappe, TA; Carrithers, JA; White, F; Lambert, CP; Evans, WJ; Dennis, RA

Published Date

  • February 2002

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 289 - 292

PubMed ID

  • 11870701

Pubmed Central ID

  • 11870701

International Standard Serial Number (ISSN)

  • 0148-639X

Digital Object Identifier (DOI)

  • 10.1002/mus.10037


  • eng

Conference Location

  • United States