PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

Journal Article

Pharmacologic inhibition or knockout of HIF-prolyl hydroxylases in mice reduces morbidity and mortality from radiation-induced gastrointestinal syndrome.

Full Text

Duke Authors

Wu, Colleen

Cited Authors

Taniguchi, CM; Miao, YR; Diep, AN; Wu, C; Rankin, EB; Atwood, TF; Xing, L; Giaccia, AJ

Published Date

May 14, 2014

Published In

Science Translational Medicine

Volume / Issue

6 / 236

Published By

American Association for the Advancement of Science (AAAS)

Electronic International Standard Serial Number (EISSN)

1946-6242

International Standard Serial Number (ISSN)

1946-6234

Digital Object Identifier (DOI)

10.1126/scitranslmed.3008523

Language

en