DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.

Journal Article (Journal Article)

BACKGROUND: DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment. METHODS: DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation to infant behaviors and temperament (n = 158). RESULTS: MEG3 DMR levels were positively associated with internalizing (β = 0.15, P = 0.044) and surgency (β = 0.19, P = 0.018) behaviors, after adjusting for birth weight, gender, gestational age at birth, maternal age at delivery, race/ethnicity, education level, smoking status, parity, and a history of anxiety or depression. Higher methylation levels at the intergenic MEG3-IG methylation regions were associated with surgency (β = 0.28, P = 0.0003) and PEG3 was positively related to externalizing (β = 0.20, P = 0.01) and negative affectivity (β = 0.18, P = 0.02). CONCLUSION: While the small sample size limits inference, these pilot data support gene-specific associations between epigenetic differences in regulatory regions of imprinted domains at birth and later infant temperament.

Full Text

Duke Authors

Cited Authors

  • Fuemmeler, BF; Lee, C-T; Soubry, A; Iversen, ES; Huang, Z; Murtha, AP; Schildkraut, JM; Jirtle, RL; Murphy, SK; Hoyo, C

Published Date

  • 2016

Published In

Volume / Issue

  • 8 /

Start / End Page

  • 59 - 67

PubMed ID

  • 27920589

Pubmed Central ID

  • PMC5127604

International Standard Serial Number (ISSN)

  • 1179-237X

Digital Object Identifier (DOI)

  • 10.4137/GEG.S40538


  • eng

Conference Location

  • United States