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The association between RT-induced changes in lung density and global lung function.

Publication ,  Journal Article
Ma, J; Zhang, J; Zhou, S; Hubbs, JL; Foltz, RJ; Hollis, DR; Light, KL; Wong, TZ; Kelsey, CR; Marks, LB
Published in: J Clin Oncol
May 20, 2008

13543 Background: Radiation (RT)-induced lung injury is a common side effect following thoracic RT. The study of RT-induced lung injury is complicated by the multiple endpoints considered (e.g., radiologic vs. symptomatic vs. functional). The association between these endpoints is not entirely clear. We herein assess the association between RT-induced changes in computed tomography (CT)-defined lung density and pulmonary function tests (PFTs). METHODS: As part of a prospective clinical study, patients receiving incidental partial lung irradiation underwent PFTs and CT scans before and serially 3-6 months after RT. Patient characteristics are as follows: the majority of patients presented with lung cancer (82%), median age was 62 (range 22-87), 50% received chemotherapy, the median prescribed RT dose was 64 Gy (range 23-86 Gy), and the median mean lung dose (MLD) was 17 Gy (4-36 Gy). Regional lung density was assessed by CT scans and global lung function by PFTs. The percent reductions in PFTs were compared to the average changes in lung density using Pearson correlations. RESULTS: 111 patients had a total of 203 concurrent CT lung density and PFT evaluations during 3- to 24-month post-RT follow-up intervals available for analyses. The average changes in lung density were quantitatively related to the percent reductions in PFTs, albeit with modest correlation coefficients (r), (see table ). The results were similar in patients treated with and without chemotherapy. CONCLUSIONS: There is a quantitative association between the degree of increase in lung density as defined by CT and the percent reduction in PFTs. These results support the concept of a parallel architecture within the lung where the sum of regional injury may be associated with changes in global function. [Table: see text] [Table: see text].

Duke Scholars

Published In

J Clin Oncol

EISSN

1527-7755

Publication Date

May 20, 2008

Volume

26

Issue

15_suppl

Start / End Page

13543

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

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Ma, J., Zhang, J., Zhou, S., Hubbs, J. L., Foltz, R. J., Hollis, D. R., … Marks, L. B. (2008). The association between RT-induced changes in lung density and global lung function. J Clin Oncol, 26(15_suppl), 13543.
Ma, J., J. Zhang, S. Zhou, J. L. Hubbs, R. J. Foltz, D. R. Hollis, K. L. Light, T. Z. Wong, C. R. Kelsey, and L. B. Marks. “The association between RT-induced changes in lung density and global lung function.J Clin Oncol 26, no. 15_suppl (May 20, 2008): 13543.
Ma J, Zhang J, Zhou S, Hubbs JL, Foltz RJ, Hollis DR, et al. The association between RT-induced changes in lung density and global lung function. J Clin Oncol. 2008 May 20;26(15_suppl):13543.
Ma, J., et al. “The association between RT-induced changes in lung density and global lung function.J Clin Oncol, vol. 26, no. 15_suppl, May 2008, p. 13543.
Ma J, Zhang J, Zhou S, Hubbs JL, Foltz RJ, Hollis DR, Light KL, Wong TZ, Kelsey CR, Marks LB. The association between RT-induced changes in lung density and global lung function. J Clin Oncol. 2008 May 20;26(15_suppl):13543.

Published In

J Clin Oncol

EISSN

1527-7755

Publication Date

May 20, 2008

Volume

26

Issue

15_suppl

Start / End Page

13543

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences