Mitochondrial Dysfunction in Lung Pathogenesis.


Journal Article (Review)

Remarkable new roles for mitochondria in calcium handling, apoptosis, heme turnover, inflammation, and oxygen and nutrient sensing have been discovered for organelles that were once thought to be simple energy converters. Although deficits in mitochondrial function are often associated with energy failure and apoptosis, working cells maintain a mitochondrial reserve that affords the organelles distinct homeostatic sensing and regulatory abilities in lung cells. As primary intracellular sources of oxidants, mitochondria serve as critical monitors and modulators of vital oxidation-reduction processes, including mitochondrial biogenesis, mitophagy, inflammasome activation, cell proliferation, and prevention of fibrosis. These processes participate in disease pathogenesis in all lung regions mainly when interference with mitochondrial quality control mechanisms impedes their roles in maintenance of lung health. Sharper identification of mitochondrial-driven signaling mechanisms in specific lung cell types will better refine our understanding of respiratory disease pathogenesis and lead to new diagnostic and therapeutic measures to support mitochondrial quality.

Full Text

Duke Authors

Cited Authors

  • Piantadosi, CA; Suliman, HB

Published Date

  • February 10, 2017

Published In

Volume / Issue

  • 79 /

Start / End Page

  • 495 - 515

PubMed ID

  • 27959621

Pubmed Central ID

  • 27959621

Electronic International Standard Serial Number (EISSN)

  • 1545-1585

Digital Object Identifier (DOI)

  • 10.1146/annurev-physiol-022516-034322


  • eng

Conference Location

  • United States