The role of immune checkpoint inhibition in the treatment of ovarian cancer.
The introduction of immune checkpoint inhibitors has revolutionized treatment of multiple cancers and has bolstered interest in this treatment approach. So far, emerging clinical data show limited clinical efficacy of these agents in ovarian cancer with objective response rates of 10-15% with some durable responses. In this review, we present emerging clinical data of completed trials of immune checkpoint inhibitors and review ongoing studies. In addition we examine the current knowledge of the tumor microenvironment of ovarian cancers with a focus on the significance of PD-L1 expression and tumor-infiltrating lymphocytes on predicting response to immune checkpoint blockade. We evaluate approaches to improve treatment outcomes through the use of predictive biomarkers and patient selection. Finally, we review management considerations including immune related adverse events and response criteria.
Duke Scholars
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- 3215 Reproductive medicine
- 3211 Oncology and carcinogenesis
- 1117 Public Health and Health Services
- 1114 Paediatrics and Reproductive Medicine
- 1112 Oncology and Carcinogenesis
Citation
Published In
DOI
ISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- 3215 Reproductive medicine
- 3211 Oncology and carcinogenesis
- 1117 Public Health and Health Services
- 1114 Paediatrics and Reproductive Medicine
- 1112 Oncology and Carcinogenesis