MASTERMIND: Bringing Microbial Diagnostics to the Clinic.

Journal Article (Journal Article)

New diagnostics are urgently needed to address emerging antimicrobial resistance. The Antibacterial Resistance Leadership Group proposes a strategy called MASTERMIND (Master Protocol for Evaluating Multiple Infection Diagnostics) for advancement of infectious diseases diagnostics. The goal of this strategy is to generate the data necessary to support US Food and Drug Administration clearance of new diagnostic tests by promoting research that might not have otherwise been feasible with conventional trial designs. MASTERMIND uses a single subject's sample(s) to evaluate multiple diagnostic tests at the same time, providing efficiencies of specimen collection and characterization. MASTERMIND also offers central trial organization, standardization of methods and definitions, and common comparators.

Full Text

Duke Authors

Cited Authors

  • Patel, R; Tsalik, EL; Petzold, E; Fowler, VG; Klausner, JD; Evans, S; Antibacterial Resistance Leadership Group (ARLG),

Published Date

  • February 1, 2017

Published In

Volume / Issue

  • 64 / 3

Start / End Page

  • 355 - 360

PubMed ID

  • 27927867

Pubmed Central ID

  • PMC5894935

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1093/cid/ciw788


  • eng

Conference Location

  • United States