CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers?


Journal Article

Aberrant Wnt signaling has been widely accepted to be a key driver of a subset of human cancers and a heavily scrutinized molecular pathway for the development of personalized medicine. In a recently published issue of Science Translational Medicine, Rosenberg and coworkers reported that the delta isoform of the CK1 family of serine/threonine kinases (CK1δ), an important mediator of intracellular Wnt signaling, is amplified and overexpressed in human breast tumors. They further demonstrated that pharmacological inhibition of CK1δ is efficacious for these cancers and implicate β-catenin signaling as a key target of CK1δ. In this perspective, we will discuss the salient features of this novel anti-cancer therapeutic approach and the challenges that lie ahead to translate it into a viable treatment option for cancer patients.

Full Text

Duke Authors

Cited Authors

  • Cheong, JK; Virshup, DM

Published Date

  • November 2016

Published In

Volume / Issue

  • 4 / 21

Start / End Page

  • 433 -

PubMed ID

  • 27942524

Pubmed Central ID

  • 27942524

International Standard Serial Number (ISSN)

  • 2305-5839

Digital Object Identifier (DOI)

  • 10.21037/atm.2016.11.07


  • eng

Conference Location

  • China