Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis.

Published

Journal Article (Review)

Autophagy is a cellular quality control and energy-providing process that is under strict control by intra- and extracellular stimuli. Recently, there has been an exponential increase in autophagy research and its implications for mammalian physiology. Autophagy deregulation is now being implicated in many human diseases, and its modulation has shown promising results in several preclinical studies. However, despite the initial discovery of autophagy as a hormone-regulated process by De Duve in the early 1960s, endocrine regulation of autophagy still remains poorly understood. In this review, we provide a critical summary of our present understanding of the basic mechanism of autophagy, its regulation by endocrine hormones, and its contribution to endocrine and metabolic homeostasis under physiological and pathological settings. Understanding the cross-regulation of hormones and autophagy on endocrine cell signaling and function will provide new insight into mammalian physiology as well as promote the development of new therapeutic strategies involving modulation of autophagy in endocrine and metabolic disorders.

Full Text

Duke Authors

Cited Authors

  • Sinha, RA; Singh, BK; Yen, PM

Published Date

  • February 2017

Published In

Volume / Issue

  • 38 / 1

Start / End Page

  • 69 - 102

PubMed ID

  • 27901588

Pubmed Central ID

  • 27901588

Electronic International Standard Serial Number (EISSN)

  • 1945-7189

International Standard Serial Number (ISSN)

  • 0163-769X

Digital Object Identifier (DOI)

  • 10.1210/er.2016-1103

Language

  • eng