Structure, inhibition, and regulation of essential lipid A enzymes.

Journal Article (Journal Article;Review)

The Raetz pathway of lipid A biosynthesis plays a vital role in the survival and fitness of Gram-negative bacteria. Research efforts in the past three decades have identified individual enzymes of the pathway and have provided a mechanistic understanding of the action and regulation of these enzymes at the molecular level. This article reviews the discovery, biochemical and structural characterization, and regulation of the essential lipid A enzymes, as well as continued efforts to develop novel antibiotics against Gram-negative pathogens by targeting lipid A biosynthesis. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop.

Full Text

Duke Authors

Cited Authors

  • Zhou, P; Zhao, J

Published Date

  • November 2017

Published In

Volume / Issue

  • 1862 / 11

Start / End Page

  • 1424 - 1438

PubMed ID

  • 27940308

Pubmed Central ID

  • PMC5466501

International Standard Serial Number (ISSN)

  • 1388-1981

Digital Object Identifier (DOI)

  • 10.1016/j.bbalip.2016.11.014


  • eng

Conference Location

  • Netherlands