Structure, inhibition, and regulation of essential lipid A enzymes.
Journal Article (Journal Article;Review)
The Raetz pathway of lipid A biosynthesis plays a vital role in the survival and fitness of Gram-negative bacteria. Research efforts in the past three decades have identified individual enzymes of the pathway and have provided a mechanistic understanding of the action and regulation of these enzymes at the molecular level. This article reviews the discovery, biochemical and structural characterization, and regulation of the essential lipid A enzymes, as well as continued efforts to develop novel antibiotics against Gram-negative pathogens by targeting lipid A biosynthesis. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop.
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Duke Authors
Cited Authors
- Zhou, P; Zhao, J
Published Date
- November 2017
Published In
Volume / Issue
- 1862 / 11
Start / End Page
- 1424 - 1438
PubMed ID
- 27940308
Pubmed Central ID
- PMC5466501
International Standard Serial Number (ISSN)
- 1388-1981
Digital Object Identifier (DOI)
- 10.1016/j.bbalip.2016.11.014
Language
- eng
Conference Location
- Netherlands