Structure, inhibition, and regulation of essential lipid A enzymes.
Publication
, Journal Article
Zhou, P; Zhao, J
Published in: Biochim Biophys Acta Mol Cell Biol Lipids
November 2017
The Raetz pathway of lipid A biosynthesis plays a vital role in the survival and fitness of Gram-negative bacteria. Research efforts in the past three decades have identified individual enzymes of the pathway and have provided a mechanistic understanding of the action and regulation of these enzymes at the molecular level. This article reviews the discovery, biochemical and structural characterization, and regulation of the essential lipid A enzymes, as well as continued efforts to develop novel antibiotics against Gram-negative pathogens by targeting lipid A biosynthesis. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop.
Duke Scholars
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Published In
Biochim Biophys Acta Mol Cell Biol Lipids
DOI
ISSN
1388-1981
Publication Date
November 2017
Volume
1862
Issue
11
Start / End Page
1424 / 1438
Location
Netherlands
Related Subject Headings
- Structure-Activity Relationship
- Protein Conformation
- Molecular Targeted Therapy
- Models, Molecular
- Lipogenesis
- Lipid A
- Gram-Negative Bacteria
- Enzymes
- Enzyme Inhibitors
- Drug Resistance, Bacterial
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhou, P., & Zhao, J. (2017). Structure, inhibition, and regulation of essential lipid A enzymes. Biochim Biophys Acta Mol Cell Biol Lipids, 1862(11), 1424–1438. https://doi.org/10.1016/j.bbalip.2016.11.014
Zhou, Pei, and Jinshi Zhao. “Structure, inhibition, and regulation of essential lipid A enzymes.” Biochim Biophys Acta Mol Cell Biol Lipids 1862, no. 11 (November 2017): 1424–38. https://doi.org/10.1016/j.bbalip.2016.11.014.
Zhou P, Zhao J. Structure, inhibition, and regulation of essential lipid A enzymes. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1424–38.
Zhou, Pei, and Jinshi Zhao. “Structure, inhibition, and regulation of essential lipid A enzymes.” Biochim Biophys Acta Mol Cell Biol Lipids, vol. 1862, no. 11, Nov. 2017, pp. 1424–38. Pubmed, doi:10.1016/j.bbalip.2016.11.014.
Zhou P, Zhao J. Structure, inhibition, and regulation of essential lipid A enzymes. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1424–1438.
Published In
Biochim Biophys Acta Mol Cell Biol Lipids
DOI
ISSN
1388-1981
Publication Date
November 2017
Volume
1862
Issue
11
Start / End Page
1424 / 1438
Location
Netherlands
Related Subject Headings
- Structure-Activity Relationship
- Protein Conformation
- Molecular Targeted Therapy
- Models, Molecular
- Lipogenesis
- Lipid A
- Gram-Negative Bacteria
- Enzymes
- Enzyme Inhibitors
- Drug Resistance, Bacterial