Disease drivers of aging.

Journal Article (Journal Article;Review)

It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

Full Text

Duke Authors

Cited Authors

  • Hodes, RJ; Sierra, F; Austad, SN; Epel, E; Neigh, GN; Erlandson, KM; Schafer, MJ; LeBrasseur, NK; Wiley, C; Campisi, J; Sehl, ME; Scalia, R; Eguchi, S; Kasinath, BS; Halter, JB; Cohen, HJ; Demark-Wahnefried, W; Ahles, TA; Barzilai, N; Hurria, A; Hunt, PW

Published Date

  • December 2016

Published In

Volume / Issue

  • 1386 / 1

Start / End Page

  • 45 - 68

PubMed ID

  • 27943360

Pubmed Central ID

  • PMC5373660

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/nyas.13299


  • eng

Conference Location

  • United States