An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.

Journal Article (Journal Article)

We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.

Full Text

Duke Authors

Cited Authors

  • Matsouaka, RA; Singhal, AB; Betensky, RA

Published Date

  • August 2018

Published In

Volume / Issue

  • 27 / 8

Start / End Page

  • 2384 - 2400

PubMed ID

  • 27920364

Pubmed Central ID

  • PMC5393279

Electronic International Standard Serial Number (EISSN)

  • 1477-0334

Digital Object Identifier (DOI)

  • 10.1177/0962280216680524


  • eng

Conference Location

  • England