An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.
Publication
, Journal Article
Matsouaka, RA; Singhal, AB; Betensky, RA
Published in: Stat Methods Med Res
August 2018
We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.
Duke Scholars
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Published In
Stat Methods Med Res
DOI
EISSN
1477-0334
Publication Date
August 2018
Volume
27
Issue
8
Start / End Page
2384 / 2400
Location
England
Related Subject Headings
- Stroke
- Statistics, Nonparametric
- Statistics & Probability
- Randomized Controlled Trials as Topic
- Oxygen Inhalation Therapy
- Mortality
- Humans
- Brain Ischemia
- 4905 Statistics
- 4202 Epidemiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Matsouaka, R. A., Singhal, A. B., & Betensky, R. A. (2018). An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res, 27(8), 2384–2400. https://doi.org/10.1177/0962280216680524
Matsouaka, Roland A., Aneesh B. Singhal, and Rebecca A. Betensky. “An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.” Stat Methods Med Res 27, no. 8 (August 2018): 2384–2400. https://doi.org/10.1177/0962280216680524.
Matsouaka RA, Singhal AB, Betensky RA. An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res. 2018 Aug;27(8):2384–400.
Matsouaka, Roland A., et al. “An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.” Stat Methods Med Res, vol. 27, no. 8, Aug. 2018, pp. 2384–400. Pubmed, doi:10.1177/0962280216680524.
Matsouaka RA, Singhal AB, Betensky RA. An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res. 2018 Aug;27(8):2384–2400.
Published In
Stat Methods Med Res
DOI
EISSN
1477-0334
Publication Date
August 2018
Volume
27
Issue
8
Start / End Page
2384 / 2400
Location
England
Related Subject Headings
- Stroke
- Statistics, Nonparametric
- Statistics & Probability
- Randomized Controlled Trials as Topic
- Oxygen Inhalation Therapy
- Mortality
- Humans
- Brain Ischemia
- 4905 Statistics
- 4202 Epidemiology