An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.
Journal Article (Journal Article)
We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.
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Duke Authors
Cited Authors
- Matsouaka, RA; Singhal, AB; Betensky, RA
Published Date
- August 2018
Published In
Volume / Issue
- 27 / 8
Start / End Page
- 2384 - 2400
PubMed ID
- 27920364
Pubmed Central ID
- PMC5393279
Electronic International Standard Serial Number (EISSN)
- 1477-0334
Digital Object Identifier (DOI)
- 10.1177/0962280216680524
Language
- eng
Conference Location
- England