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Tumor-specific peptide vaccination in newly-diagnosed patients with GBM.

Publication ,  Journal Article
Heimberger, AB; Hussain, SF; Aldape, K; Sawaya, R; Archer, GA; Friedman, H; Reardon, D; Friedman, A; Bigner, D; Sampson, JH
Published in: J Clin Oncol
June 20, 2006

2529 Background: Despite multimodality approaches, survival with GBM is dismal. Induction of immune responses to suppress the infiltrative, residual component with an easily manufactured and administered immunotherapy has been a theoretical ideal. The epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific cell surface protein expressed on approximately 40% of GBMs. METHODS: Newly-diagnosed GBM patients with a gross-total resection, a KPS ≥70, and EGFRvIII+, after undergoing radiation with concurrent temozolomide without tumor progression, were eligible to receive EGFRvIII peptide vaccination i.d. with GM-CSF. Primary endpoint was safety. RESULTS: Accrual began in 06/14/2004 and is now complete. 19 patients were enrolled. Median follow-up is 18 months. Toxicity was minimal and without evidence of autoimmunity. Humoral and cellular immune responses were generated. Median TTP from surgery in vaccine-treated patients is 12 months (n = 12), comparing favorably with a historical matched unvaccinated cohort (gross total resection without progression during radiation, KPS≥70, EGFRvIII+) that had a median TTP of 7.1 months (n = 39) (p = 0.0058). These results also compared favorably with those reported for concurrent temozolomide and radiation followed by adjuvant temozolomide, with a median TTP of 6.9 months. Median survival in this trial has exceeded 18 months which compares favorably to all published analyses accounting for all known prognostic indicators. Among recurrent tumors evaluated by immunohistochemistry, 100% no longer expressed the EGFRvIII, suggesting immunological activation that eliminated EGFRvIII-expressing cells, as well as one potential mechanism of treatment failure. CONCLUSIONS: EGFRvIII peptide vaccination warrants further investigation in a larger randomized clinical trial in patients with EGFRvIII-expressing tumors. No significant financial relationships to disclose.

Duke Scholars

Published In

J Clin Oncol

EISSN

1527-7755

Publication Date

June 20, 2006

Volume

24

Issue

18_suppl

Start / End Page

2529

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Heimberger, A. B., Hussain, S. F., Aldape, K., Sawaya, R., Archer, G. A., Friedman, H., … Sampson, J. H. (2006). Tumor-specific peptide vaccination in newly-diagnosed patients with GBM. J Clin Oncol, 24(18_suppl), 2529.
Heimberger, A. B., S. F. Hussain, K. Aldape, R. Sawaya, G. A. Archer, H. Friedman, D. Reardon, A. Friedman, D. Bigner, and J. H. Sampson. “Tumor-specific peptide vaccination in newly-diagnosed patients with GBM.J Clin Oncol 24, no. 18_suppl (June 20, 2006): 2529.
Heimberger AB, Hussain SF, Aldape K, Sawaya R, Archer GA, Friedman H, et al. Tumor-specific peptide vaccination in newly-diagnosed patients with GBM. J Clin Oncol. 2006 Jun 20;24(18_suppl):2529.
Heimberger, A. B., et al. “Tumor-specific peptide vaccination in newly-diagnosed patients with GBM.J Clin Oncol, vol. 24, no. 18_suppl, June 2006, p. 2529.
Heimberger AB, Hussain SF, Aldape K, Sawaya R, Archer GA, Friedman H, Reardon D, Friedman A, Bigner D, Sampson JH. Tumor-specific peptide vaccination in newly-diagnosed patients with GBM. J Clin Oncol. 2006 Jun 20;24(18_suppl):2529.

Published In

J Clin Oncol

EISSN

1527-7755

Publication Date

June 20, 2006

Volume

24

Issue

18_suppl

Start / End Page

2529

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences