Dichotomous roles of TGF-β in human cancer.

Journal Article (Review)

Transforming growth factor-β (TGF-β) mediates numerous biological processes, including embryonic development and the maintenance of cellular homeostasis in a context-dependent manner. Consistent with its central role in maintaining cellular homeostasis, inhibition of TGF-β signaling results in disruption of normal homeostatic processes and subsequent carcinogenesis, defining the TGF-β signaling pathway as a tumor suppressor. However, once carcinogenesis is initiated, the TGF-β signaling pathway promotes cancer progression. This dichotomous function of the TGF-β signaling pathway is mediated through altering effects on both the cancer cells, by inducing apoptosis and inhibiting proliferation, and the tumor microenvironment, by promoting angiogenesis and inhibiting immunosurveillance. Current studies support inhibition of TGF-β signaling either alone, or in conjunction with anti-angiogenic therapy or immunotherapy as a promising strategy for the treatment of human cancers.

Full Text

Duke Authors

Cited Authors

  • Huang, JJ; Blobe, GC

Published Date

  • October 2016

Published In

Volume / Issue

  • 44 / 5

Start / End Page

  • 1441 - 1454

PubMed ID

  • 27911726

Electronic International Standard Serial Number (EISSN)

  • 1470-8752

International Standard Serial Number (ISSN)

  • 0300-5127

Digital Object Identifier (DOI)

  • 10.1042/bst20160065

Language

  • eng