A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.

Published

Journal Article

To test the hypothesis that chronic treatment of early-stage Huntington disease (HD) with high-dose coenzyme Q10 (CoQ) will slow the progressive functional decline of HD.We performed a multicenter randomized, double-blind, placebo-controlled trial. Patients with early-stage HD (n = 609) were enrolled at 48 sites in the United States, Canada, and Australia from 2008 to 2012. Patients were randomized to receive either CoQ 2,400 mg/d or matching placebo, then followed for 60 months. The primary outcome variable was the change from baseline to month 60 in Total Functional Capacity score (for patients who survived) combined with time to death (for patients who died) analyzed using a joint-rank analysis approach.An interim analysis for futility revealed a conditional power of <5% for the primary analysis, prompting premature conclusion in July 2014. No statistically significant differences were seen between treatment groups for the primary or secondary outcome measures. CoQ was generally safe and well-tolerated throughout the study.These data do not justify use of CoQ as a treatment to slow functional decline in HD.NCT00608881.This article provides Class I evidence that CoQ does not slow the progressive functional decline of patients with HD.

Full Text

Duke Authors

Cited Authors

  • McGarry, A; McDermott, M; Kieburtz, K; de Blieck, EA; Beal, F; Marder, K; Ross, C; Shoulson, I; Gilbert, P; Mallonee, WM; Guttman, M; Wojcieszek, J; Kumar, R; LeDoux, MS; Jenkins, M; Rosas, HD; Nance, M; Biglan, K; Como, P; Dubinsky, RM; Shannon, KM; O'Suilleabhain, P; Chou, K; Walker, F; Martin, W; Wheelock, VL; McCusker, E; Jankovic, J; Singer, C; Sanchez-Ramos, J; Scott, B; Suchowersky, O; Factor, SA; Higgins, DS; Molho, E; Revilla, F; Caviness, JN; Friedman, JH; Perlmutter, JS; Feigin, A; Anderson, K; Rodriguez, R; McFarland, NR; Margolis, RL; Farbman, ES; Raymond, LA; Suski, V; Kostyk, S; Colcher, A; Seeberger, L; Epping, E; Esmail, S; Diaz, N; Fung, WLA; Diamond, A; Frank, S; Hanna, P; Hermanowicz, N; Dure, LS; Cudkowicz, M; Huntington Study Group 2CARE Investigators and Coordinators,

Published Date

  • January 2017

Published In

Volume / Issue

  • 88 / 2

Start / End Page

  • 152 - 159

PubMed ID

  • 27913695

Pubmed Central ID

  • 27913695

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/WNL.0000000000003478

Language

  • eng