The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer.
Publication
, Journal Article
Zhang, JY; Selim, MA
Published in: Am J Cancer Res
2012
The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.
Duke Scholars
Published In
Am J Cancer Res
ISSN
2156-6976
Publication Date
2012
Volume
2
Issue
6
Start / End Page
691 / 698
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, J. Y., & Selim, M. A. (2012). The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer. Am J Cancer Res, 2(6), 691–698.
Zhang, Jennifer Y., and Maria Angelica Selim. “The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer.” Am J Cancer Res 2, no. 6 (2012): 691–98.
Zhang JY, Selim MA. The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer. Am J Cancer Res. 2012;2(6):691–8.
Zhang, Jennifer Y., and Maria Angelica Selim. “The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer.” Am J Cancer Res, vol. 2, no. 6, 2012, pp. 691–98.
Zhang JY, Selim MA. The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer. Am J Cancer Res. 2012;2(6):691–698.
Published In
Am J Cancer Res
ISSN
2156-6976
Publication Date
2012
Volume
2
Issue
6
Start / End Page
691 / 698
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis