The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer.

Journal Article (Journal Article)

The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.

Full Text

Duke Authors

Cited Authors

  • Zhang, JY; Selim, MA

Published Date

  • 2012

Published In

Volume / Issue

  • 2 / 6

Start / End Page

  • 691 - 698

PubMed ID

  • 23226615

Pubmed Central ID

  • PMC3512184

International Standard Serial Number (ISSN)

  • 2156-6976

Language

  • eng

Conference Location

  • United States