Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.

Journal Article (Journal Article)

Intermediary metabolism provides substrates that shape epigenetic status, but whether this interaction can be responsible for oncogenesis is largely unknown. In a recent issue of Nature, Kottakis et al. (2016) now show that the common tumor suppressor gene LKB1 can function by mediating this connection through an LKB1/AMPK/mTOR signaling axis.

Full Text

Duke Authors

Cited Authors

  • Gao, X; Locasale, JW

Published Date

  • December 13, 2016

Published In

Volume / Issue

  • 24 / 6

Start / End Page

  • 777 - 779

PubMed ID

  • 27974177

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2016.11.012


  • eng

Conference Location

  • United States