Reduction of cerebellar volume in major depression: A controlled MRI study

Journal Article (Journal Article)

A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression and compared with 35 normal controls. The mean cerebellar volume of depressed patients was significantly smaller than the controls. This preliminary study adds new evidence for the possible participation of the cerebellum in the pathophysiology of major depression and warrants further investigation in this area. Depression 1:156–158 (1993). © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company

Full Text

Duke Authors

Cited Authors

  • Escalona, PR; Early, B; McDonald, WM; Doraiswamy, PM; Shah, SA; Husain, MM; Boyko, OB; Figiel, GS; Ellinwood, EH; Nemeroff, CB; Krishnan, KRR

Published Date

  • January 1, 1993

Published In

Volume / Issue

  • 1 / 3

Start / End Page

  • 156 - 158

Electronic International Standard Serial Number (EISSN)

  • 1522-7162

International Standard Serial Number (ISSN)

  • 1062-6417

Digital Object Identifier (DOI)

  • 10.1002/depr.3050010307

Citation Source

  • Scopus