High-speed photoacoustic microscopy of mouse cortical microhemodynamics.

Journal Article (Journal Article)

We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

Full Text

Duke Authors

Cited Authors

  • Lin, L; Yao, J; Zhang, R; Chen, C-C; Huang, C-H; Li, Y; Wang, L; Chapman, W; Zou, J; Wang, LV

Published Date

  • June 2017

Published In

Volume / Issue

  • 10 / 6-7

Start / End Page

  • 792 - 798

PubMed ID

  • 28009098

Pubmed Central ID

  • PMC5576888

Electronic International Standard Serial Number (EISSN)

  • 1864-0648

International Standard Serial Number (ISSN)

  • 1864-063X

Digital Object Identifier (DOI)

  • 10.1002/jbio.201600236


  • eng