Striatal denervation pattern predicts levodopa effects on sequence learning in Parkinson's disease.


Journal Article

Mild to moderate Parkinson's disease shows more denervation in the posterodorsal striatum and sparing of the anteroventral striatum. Dopaminergic medications can interfere with anteroventral striatum function by overdosing this relatively intact structure. The authors determined how regional striatal denervation affects medication-associated sequence learning impairment in Parkinson's disease. Eighteen Parkinson's patients performed motor sequence learning on and off levodopa. Patients underwent (11)C-dihydrotetrabenazine positron emission tomography scans to measure nigrostriatal denervation. Patients with more preserved putamen were more likely to exhibit levodopa-associated sequence learning impairments. Furthermore, the ratio of denervation in the anterior to posterior dorsal putamen predicted the level of learning differences on and off levodopa. These results demonstrate that the spatial pattern of nigrostriatal dopaminergic denervation predicts medication responsiveness for motor sequence learning.

Full Text

Cited Authors

  • Kwak, Y; Bohnen, NI; Müller, MLTM; Dayalu, P; Seidler, RD

Published Date

  • January 2013

Published In

Volume / Issue

  • 45 / 5

Start / End Page

  • 423 - 429

PubMed ID

  • 23971968

Pubmed Central ID

  • 23971968

Electronic International Standard Serial Number (EISSN)

  • 1940-1027

International Standard Serial Number (ISSN)

  • 0022-2895

Digital Object Identifier (DOI)

  • 10.1080/00222895.2013.817380


  • eng