Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI.

Published

Journal Article

To assess changes in liver proton density fat fraction (PDFF) and R 2* measurements in the presence of changes in tissue relaxation rates induced by administrating gadoxetic acid, using two different image reconstruction methods at 3T MRI.Forty-five patients were imaged at 3T with chemical-shift-based MRI sequences before and 20 min after administration of gadoxetic acid. Image reconstructions were performed using hybrid and complex methods to obtain PDFF and R 2* images. A single radiologist measured PDFF and R 2* values on precontrast and postcontrast images. Precontrast and postcontrast PDFF values were compared using intraclass correlation coefficient (ICC), linear regression, and Bland-Altman analysis. Changes in R 2* values from precontrast to postcontrast were correlated with relative liver enhancement (RLE) based on signal intensities on T 1-weighted images using Spearman's rank correlation.PDFF values were similar between precontrast and postcontrast images (ICC = 0.99, linear regression slopes = 0.98, mean difference = -0.21 to -0.31%). PDFF measurements were stable between precontrast and postcontrast images. Changes in R 2* values were correlated with RLE (p < 0.001, r = 0.49-0.71).PDFF measurements from both image reconstruction methods are stable in the presence of changes in tissue relaxation rates after administering gadoxetic acid at 3T MRI. Changes in R 2* values correlate with established measures of gadoxetic acid uptake based on T 1-weighted images.

Full Text

Duke Authors

Cited Authors

  • Sofue, K; Zhong, X; Nickel, MD; Dale, BM; Bashir, MR

Published Date

  • August 2016

Published In

Volume / Issue

  • 41 / 8

Start / End Page

  • 1555 - 1564

PubMed ID

  • 27052456

Pubmed Central ID

  • 27052456

Electronic International Standard Serial Number (EISSN)

  • 2366-0058

International Standard Serial Number (ISSN)

  • 2366-004X

Digital Object Identifier (DOI)

  • 10.1007/s00261-016-0728-5

Language

  • eng