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Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI.

Publication ,  Journal Article
Sofue, K; Zhong, X; Nickel, MD; Dale, BM; Bashir, MR
Published in: Abdom Radiol (NY)
August 2016

OBJECTIVE: To assess changes in liver proton density fat fraction (PDFF) and R 2* measurements in the presence of changes in tissue relaxation rates induced by administrating gadoxetic acid, using two different image reconstruction methods at 3T MRI. METHODS: Forty-five patients were imaged at 3T with chemical-shift-based MRI sequences before and 20 min after administration of gadoxetic acid. Image reconstructions were performed using hybrid and complex methods to obtain PDFF and R 2* images. A single radiologist measured PDFF and R 2* values on precontrast and postcontrast images. Precontrast and postcontrast PDFF values were compared using intraclass correlation coefficient (ICC), linear regression, and Bland-Altman analysis. Changes in R 2* values from precontrast to postcontrast were correlated with relative liver enhancement (RLE) based on signal intensities on T 1-weighted images using Spearman's rank correlation. RESULTS: PDFF values were similar between precontrast and postcontrast images (ICC = 0.99, linear regression slopes = 0.98, mean difference = -0.21 to -0.31%). PDFF measurements were stable between precontrast and postcontrast images. Changes in R 2* values were correlated with RLE (p < 0.001, r = 0.49-0.71). CONCLUSIONS: PDFF measurements from both image reconstruction methods are stable in the presence of changes in tissue relaxation rates after administering gadoxetic acid at 3T MRI. Changes in R 2* values correlate with established measures of gadoxetic acid uptake based on T 1-weighted images.

Duke Scholars

Published In

Abdom Radiol (NY)

DOI

EISSN

2366-0058

Publication Date

August 2016

Volume

41

Issue

8

Start / End Page

1555 / 1564

Location

United States

Related Subject Headings

  • Young Adult
  • Reproducibility of Results
  • Protons
  • Prospective Studies
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases
  • Liver
  • Image Processing, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sofue, K., Zhong, X., Nickel, M. D., Dale, B. M., & Bashir, M. R. (2016). Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI. Abdom Radiol (NY), 41(8), 1555–1564. https://doi.org/10.1007/s00261-016-0728-5
Sofue, Keitaro, Xiaodong Zhong, Marcel D. Nickel, Brian M. Dale, and Mustafa R. Bashir. “Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI.Abdom Radiol (NY) 41, no. 8 (August 2016): 1555–64. https://doi.org/10.1007/s00261-016-0728-5.
Sofue K, Zhong X, Nickel MD, Dale BM, Bashir MR. Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI. Abdom Radiol (NY). 2016 Aug;41(8):1555–64.
Sofue, Keitaro, et al. “Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI.Abdom Radiol (NY), vol. 41, no. 8, Aug. 2016, pp. 1555–64. Pubmed, doi:10.1007/s00261-016-0728-5.
Sofue K, Zhong X, Nickel MD, Dale BM, Bashir MR. Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI. Abdom Radiol (NY). 2016 Aug;41(8):1555–1564.
Journal cover image

Published In

Abdom Radiol (NY)

DOI

EISSN

2366-0058

Publication Date

August 2016

Volume

41

Issue

8

Start / End Page

1555 / 1564

Location

United States

Related Subject Headings

  • Young Adult
  • Reproducibility of Results
  • Protons
  • Prospective Studies
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases
  • Liver
  • Image Processing, Computer-Assisted