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SU-E-J-68: Evaluation of Liver Deformation During Breathing Using Deformable Image Registration: A Comparison Between 4D CT and 4D MRI.

Publication ,  Journal Article
Liang, X; Czito, B; Palta, M; Bashir, M; Yin, F; Cai, J
Published in: Med Phys
June 2014

PURPOSE: It is of clinical interest to study liver deformation during breathing by applying deformable image registration (DIR) on respiratory correlated 4D images. This study aims to evaluate and compare the accuracy of DIR-derived liver deformation based on 4D CT and 4D MRI. METHODS: 4D CT, 4D MR and cine MR images of liver region were acquired from 5 patients with liver cancer under an IRB-approved protocol. Tumor trajectories were tracked from cine MR images. DVFs from 4D CT and 4D MR were generated via DIR implemented in Velocity AI. To enable comparison between DVFs and tumor trajectories from cine images, deformation vectors from each frame were linked together, forming DVF-based trajectories. All DVF-based trajectories within each tumor region were averaged. Absolute difference, relative difference and correlation coefficient between each pair of averaged DVF-based trajectory and trajectory from cine MR images were calculated. RESULTS: All metrics did not give consistent indications of which modality can provide more accurate DVFs. In superior-inferior (SI) direction, averaging over all the five patients, 4D CT trajectories exhibited smaller absolute (2.05±0.52mm) and relative difference (0.43±0.14) and larger correlation coefficient (0.92±0.06) than 4D MR trajectories (2.54±1.45mm, 0.47±0.18, 0.88±0.10) whereas 4D MR (1.02±1.20mm, 0.90±0.69, 0.59±0.30) surpassed 4D CT (1.35±1.42mm, 1.35±1.25, 0.12±0.64) in every metric in right-left direction. In anterior-posterior direction, 4D MR trajectories has smaller absolute (1.17±0.74mm) and relative difference (0.50±0.18) with slightly smaller correlation coefficient (0.72±0.23) than 4D CT trajectories (1.51±0.64mm, 0.69±0.09, 0.75±0.26). CONCLUSION: We have implemented a novel approach for evaluating accuracy of DVFs based on 4D imaging for studying liver deformation. Initial results indicate that DVFs from 4D CT and 4D MRI are comparable. Further study on more patients is warranted and is undergoing to determine whether there is significant difference between 4D CT and 4D MRI.

Duke Scholars

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2014

Volume

41

Issue

6

Start / End Page

171

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liang, X., Czito, B., Palta, M., Bashir, M., Yin, F., & Cai, J. (2014). SU-E-J-68: Evaluation of Liver Deformation During Breathing Using Deformable Image Registration: A Comparison Between 4D CT and 4D MRI. Med Phys, 41(6), 171. https://doi.org/10.1118/1.4888120
Liang, X., B. Czito, M. Palta, M. Bashir, F. Yin, and J. Cai. “SU-E-J-68: Evaluation of Liver Deformation During Breathing Using Deformable Image Registration: A Comparison Between 4D CT and 4D MRI.Med Phys 41, no. 6 (June 2014): 171. https://doi.org/10.1118/1.4888120.
Liang, X., et al. “SU-E-J-68: Evaluation of Liver Deformation During Breathing Using Deformable Image Registration: A Comparison Between 4D CT and 4D MRI.Med Phys, vol. 41, no. 6, June 2014, p. 171. Pubmed, doi:10.1118/1.4888120.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2014

Volume

41

Issue

6

Start / End Page

171

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences