Application of Williams' design for bioequivalence trials

Journal Article

This paper illustrates the application of Williams' design to bioequivalence trials. The replicated and variance-balanced crossover design is briefly outlined. Statistical methods for analysis of a Williams' design are discussed. Results are presented from a single dose/multiple doses study for assessment of bioequivalence.

Duke Authors

Cited Authors

  • Mohandoss, E; Chow, SC; Ki, FYC

Published Date

  • 1995

Published In

  • Drug Information Journal

Volume / Issue

  • 29 / 3

Start / End Page

  • 1029 - 1038