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Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast.

Publication ,  Journal Article
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), ; Correa, C; McGale, P; Taylor, C; Wang, Y; Clarke, M; Davies, C; Peto, R; Bijker, N ...
Published in: J Natl Cancer Inst Monogr
2010

Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive cancer) by 15.2% (SE 1.6%, 12.9% vs 28.1% 2 P <.00001), and it was effective regardless of the age at diagnosis, extent of breast-conserving surgery, use of tamoxifen, method of DCIS detection, margin status, focality, grade, comedonecrosis, architecture, or tumor size. The proportional reduction in ipsilateral breast events was greater in older than in younger women (2P < .0004 for difference between proportional reductions; 10-year absolute risks: 18.5% vs 29.1% at ages <50 years, 10.8% vs 27.8% at ages ≥ 50 years) but did not differ significantly according to any other available factor. Even for women with negative margins and small low-grade tumors, the absolute reduction in the 10-year risk of ipsilateral breast events was 18.0% (SE 5.5, 12.1% vs 30.1%, 2P = .002). After 10 years of follow-up, there was, however, no significant effect on breast cancer mortality, mortality from causes other than breast cancer, or all-cause mortality.

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Published In

J Natl Cancer Inst Monogr

DOI

EISSN

1745-6614

Publication Date

2010

Volume

2010

Issue

41

Start / End Page

162 / 177

Location

United States

Related Subject Headings

  • Tamoxifen
  • Randomized Controlled Trials as Topic
  • Radiotherapy, Adjuvant
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Neoplasm Recurrence, Local
  • Multicenter Studies as Topic
  • Middle Aged
  • Meta-Analysis as Topic
  • Mastectomy, Segmental
 

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Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), ., Correa, C., McGale, P., Taylor, C., Wang, Y., Clarke, M., … Darby, S. (2010). Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr, 2010(41), 162–177. https://doi.org/10.1093/jncimonographs/lgq039
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), S., C. Correa, P. McGale, C. Taylor, Y. Wang, M. Clarke, C. Davies, et al. “Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast.J Natl Cancer Inst Monogr 2010, no. 41 (2010): 162–77. https://doi.org/10.1093/jncimonographs/lgq039.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Correa C, McGale P, Taylor C, Wang Y, Clarke M, et al. Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr. 2010;2010(41):162–77.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), S., et al. “Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast.J Natl Cancer Inst Monogr, vol. 2010, no. 41, 2010, pp. 162–77. Pubmed, doi:10.1093/jncimonographs/lgq039.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Correa C, McGale P, Taylor C, Wang Y, Clarke M, Davies C, Peto R, Bijker N, Solin L, Darby S. Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr. 2010;2010(41):162–177.
Journal cover image

Published In

J Natl Cancer Inst Monogr

DOI

EISSN

1745-6614

Publication Date

2010

Volume

2010

Issue

41

Start / End Page

162 / 177

Location

United States

Related Subject Headings

  • Tamoxifen
  • Randomized Controlled Trials as Topic
  • Radiotherapy, Adjuvant
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Neoplasm Recurrence, Local
  • Multicenter Studies as Topic
  • Middle Aged
  • Meta-Analysis as Topic
  • Mastectomy, Segmental