Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study.

Journal Article (Journal Article)

Ninety-eight children with solid tumors resistant to conventional chemotherapy received adriamycin 90 mg/m2, either as a single intravenous injection or in 6 divided doses administered every 6 hours. Of the 88 evaluable children, 6 (7%) achieved a complete response and 26 (29%) achieved a partial response. Tumors which demonstrated significant response rates were: neuroblastoma (9/18), Wilms' tumor (7/13), rhabdomyosarcoma (4/11), and lymphoma (4/8). The toxicities observed with this regimen included: alopecia, leukopenia, thrombocytopenia, nausea, vomiting, stomatitis, febrile episodes, and ST-segment changes.

Full Text

Duke Authors

Cited Authors

  • Ragab, AH; Sutow, WW; Komp, DM; Starling, KA; Lyon, GM; George, S

Published Date

  • November 1, 1975

Published In

Volume / Issue

  • 36 / 5

Start / End Page

  • 1567 - 1576

PubMed ID

  • 1192348

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197511)36:5<1567::aid-cncr2820360505>3.0.co;2-i

Language

  • eng

Conference Location

  • United States