Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study.
Journal Article (Journal Article)
Ninety-eight children with solid tumors resistant to conventional chemotherapy received adriamycin 90 mg/m2, either as a single intravenous injection or in 6 divided doses administered every 6 hours. Of the 88 evaluable children, 6 (7%) achieved a complete response and 26 (29%) achieved a partial response. Tumors which demonstrated significant response rates were: neuroblastoma (9/18), Wilms' tumor (7/13), rhabdomyosarcoma (4/11), and lymphoma (4/8). The toxicities observed with this regimen included: alopecia, leukopenia, thrombocytopenia, nausea, vomiting, stomatitis, febrile episodes, and ST-segment changes.
Full Text
Duke Authors
Cited Authors
- Ragab, AH; Sutow, WW; Komp, DM; Starling, KA; Lyon, GM; George, S
Published Date
- November 1, 1975
Published In
Volume / Issue
- 36 / 5
Start / End Page
- 1567 - 1576
PubMed ID
- 1192348
International Standard Serial Number (ISSN)
- 0008-543X
Digital Object Identifier (DOI)
- 10.1002/1097-0142(197511)36:5<1567::aid-cncr2820360505>3.0.co;2-i
Language
- eng
Conference Location
- United States