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Comparison of prednisolone, vincristine, methotrexate, and 6-mercaptopurine vs. vincristine and prednisone induction therapy in childhood acute leukemia.

Publication ,  Journal Article
Berry, DH; Pullen, J; George, S; Vietti, TJ; Sullivan, MP; Fernbach, D
Published in: Cancer
July 1975

This was designed to compare vincristine-prednisone (VP) vs. prednisolone, vincristine, methotrexate, and 6-mercaptopurine (POMP) with respect to response rates and toxicity for induction therapy in acute leukemia. Children with acute lymphoblastic, acute undifferentiated, or acute stem cell leukemia were stratified on the basis of initial leukocyte count and age, then randomly assigned to POMP or VP induction therapy. On the POMP regime, 19/34 (56%) achieved complete remission (CR), 7 achieved partial remission (PR), and 5 did not respond (NR). Three died prior to day 25 of the study. On the VP regime, 37/39 (95%) had CR, and 2 NR. On the VP regime neither sepsis nor toxicity were significant problems. The POMP regime had a higher incidence of sepsis and other toxicities frequently causing therapy interruption, but not enequivocally causing the poor response rate. Several other factors were evaluated as possible causes for the lack of response to POMP therapy.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

July 1975

Volume

36

Issue

1

Start / End Page

98 / 102

Location

United States

Related Subject Headings

  • Vincristine
  • Prednisone
  • Prednisolone
  • Oncology & Carcinogenesis
  • Methotrexate
  • Mercaptopurine
  • Leukemia
  • Infant
  • Humans
  • Drug Therapy, Combination
 

Citation

APA
Chicago
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MLA
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Berry, D. H., Pullen, J., George, S., Vietti, T. J., Sullivan, M. P., & Fernbach, D. (1975). Comparison of prednisolone, vincristine, methotrexate, and 6-mercaptopurine vs. vincristine and prednisone induction therapy in childhood acute leukemia. Cancer, 36(1), 98–102. https://doi.org/10.1002/1097-0142(197507)36:1<98::aid-cncr2820360105>3.0.co;2-r
Berry, D. H., J. Pullen, S. George, T. J. Vietti, M. P. Sullivan, and D. Fernbach. “Comparison of prednisolone, vincristine, methotrexate, and 6-mercaptopurine vs. vincristine and prednisone induction therapy in childhood acute leukemia.Cancer 36, no. 1 (July 1975): 98–102. https://doi.org/10.1002/1097-0142(197507)36:1<98::aid-cncr2820360105>3.0.co;2-r.
Berry, D. H., et al. “Comparison of prednisolone, vincristine, methotrexate, and 6-mercaptopurine vs. vincristine and prednisone induction therapy in childhood acute leukemia.Cancer, vol. 36, no. 1, July 1975, pp. 98–102. Pubmed, doi:10.1002/1097-0142(197507)36:1<98::aid-cncr2820360105>3.0.co;2-r.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

July 1975

Volume

36

Issue

1

Start / End Page

98 / 102

Location

United States

Related Subject Headings

  • Vincristine
  • Prednisone
  • Prednisolone
  • Oncology & Carcinogenesis
  • Methotrexate
  • Mercaptopurine
  • Leukemia
  • Infant
  • Humans
  • Drug Therapy, Combination