PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model.

Journal Article (Journal Article)

An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.

Full Text

Duke Authors

Glower Jr., Donald D.

Cited Authors

Nho, K; Glower, D; Bredehoeft, S; Shankar, H; Shorr, R; Abuchowski, A

Published Date

1992

Published In

Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology

Volume / Issue

20 / 2-4

Start / End Page

511 - 524

PubMed ID

1391472

International Standard Serial Number (ISSN)

1055-7172

Digital Object Identifier (DOI)

10.3109/10731199209119677

Language

eng

Conference Location

United States