PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model.

Journal Article (Journal Article)

An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.

Full Text

Duke Authors

Cited Authors

  • Nho, K; Glower, D; Bredehoeft, S; Shankar, H; Shorr, R; Abuchowski, A

Published Date

  • 1992

Published In

Volume / Issue

  • 20 / 2-4

Start / End Page

  • 511 - 524

PubMed ID

  • 1391472

International Standard Serial Number (ISSN)

  • 1055-7172

Digital Object Identifier (DOI)

  • 10.3109/10731199209119677


  • eng

Conference Location

  • United States