Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice

Published

Journal Article

Analysis of the skeletal phenotypes caused by the genetic inactivation of individual Bmps, along with the study of their expression patterns, suggest possible functional redundancy of these molecules. To investigate the effect on skeleton development of the combined absence of some Bmp genes expressed in the same areas, we have intercrossed heterozygous Bmp7 mice with Bmp2(+/), Bmp4(+/-), or Bmp5(+/-) animals. Bmp2/7 and Bmp5/7 double heterozygous animals do not present with any abnormalities. In contrast, Bmp4/7 double heterozygotes develop minor defects in two restricted areas of the skeleton, the rib cage, and the distal part of the limbs. In the ribs, Bmp4 and Bmp7 seem to act in the same pathway to assure proper guidance of mesenchymal condensations of the ribs extending toword the sternum. In the limbs, these molecules appear to play a similar role in controlling digit number, possibly through induction of apoptosis in the interdigital and anterior mesenchyme.

Full Text

Duke Authors

Published Date

  • July 15, 1998

Published In

Volume / Issue

  • 22 / 4

Start / End Page

  • 340 - 348

International Standard Serial Number (ISSN)

  • 0192-253X

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1520-6408(1998)22:4<340::AID-DVG4>3.0.CO;2-6

Citation Source

  • Scopus