Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.

Published

Journal Article (Review)

Autism spectrum disorders (ASDs) present unique challenges in the fields of genetics and neurobiology because of the clinical and molecular heterogeneity underlying these disorders. Genetic mutations found in ASD patients provide opportunities to dissect the molecular and circuit mechanisms underlying autistic behaviors using animal models. Ongoing studies of genetically modified models have offered critical insight into possible common mechanisms arising from different mutations, but links between molecular abnormalities and behavioral phenotypes remain elusive. The challenges encountered in modeling autism in mice demand a new analytic paradigm that integrates behavioral assessment with circuit-level analysis in genetically modified models with strong construct validity.

Full Text

Duke Authors

Cited Authors

  • Hulbert, SW; Jiang, Y-H

Published Date

  • May 3, 2016

Published In

Volume / Issue

  • 321 /

Start / End Page

  • 3 - 23

PubMed ID

  • 26733386

Pubmed Central ID

  • 26733386

Electronic International Standard Serial Number (EISSN)

  • 1873-7544

Digital Object Identifier (DOI)

  • 10.1016/j.neuroscience.2015.12.040

Language

  • eng

Conference Location

  • United States