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The NEXT-1 (Next generation pErsonalized tX with mulTi-omics and preclinical model) trial: prospective molecular screening trial of metastatic solid cancer patients, a feasibility analysis.

Publication ,  Journal Article
Kim, ST; Lee, J; Hong, M; Park, K; Park, JO; Ahn, T; Park, SH; Park, YS; Lim, HY; Sun, J-M; Ahn, JS; Ahn, M-J; Kim, HC; Sohn, TS; Choi, DI ...
Published in: Oncotarget
October 20, 2015

We conducted a prospective genomic screening trial with high throughput sequencing and copy number variation (CNV) assay, and immunohistochemistry array in metastatic solid cancer patients. We used Ion AmpliSeq Cancer Hotspot Panel v2 and nCounter Copy Number Variation Assay (21 genes) to identify molecular targets for potential matched therapy. Metastatic solid tumor patients were prospectively consented for molecular profiling tests. The primary outcome for this trial was the feasibility of molecular tests and response rate (matched vs non-matched treatment). Between November 2013 and August 2014, a total of 428 metastatic solid tumor patients were enrolled on to this study. The mutational profiles were obtained for 407 (95.1%) patients. CNV 21-gene assays were successfully performed in 281 (65.7%) of 428 patients. Of the 407 patients with molecular profiling results, 342 (84.0%) patients had one or more aberrations detected. Of the 342 patients, 103 patients were matched to molecularly targeted agents in the context of clinical trials or clinical practice. The response rate was significantly higher in the genome-matched treated group for gastrointestinal/hepatobiliary/rare tumors (matched vs non-matched treatment, 42.6% vs 24.3%, P = .009) and lung cancer cohort (matched vs non-matched treatment, 61.2% vs 28.6% < P = .001) when compared with the non-matched group. In this trial, we demonstrate that genome-matched treatment based on molecular profiling result in better treatment outcome in terms of response rate.

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Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

October 20, 2015

Volume

6

Issue

32

Start / End Page

33358 / 33368

Location

United States

Related Subject Headings

  • Young Adult
  • Precision Medicine
  • Neoplasms
  • Neoplasm Metastasis
  • Molecular Diagnostic Techniques
  • Middle Aged
  • Male
  • Humans
  • High-Throughput Nucleotide Sequencing
  • Genomics
 

Citation

APA
Chicago
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Kim, S. T., Lee, J., Hong, M., Park, K., Park, J. O., Ahn, T., … Kang, W. K. (2015). The NEXT-1 (Next generation pErsonalized tX with mulTi-omics and preclinical model) trial: prospective molecular screening trial of metastatic solid cancer patients, a feasibility analysis. Oncotarget, 6(32), 33358–33368. https://doi.org/10.18632/oncotarget.5188
Kim, Seung Tae, Jeeyun Lee, Mineui Hong, Kyunghee Park, Joon Oh Park, TaeJin Ahn, Se Hoon Park, et al. “The NEXT-1 (Next generation pErsonalized tX with mulTi-omics and preclinical model) trial: prospective molecular screening trial of metastatic solid cancer patients, a feasibility analysis.Oncotarget 6, no. 32 (October 20, 2015): 33358–68. https://doi.org/10.18632/oncotarget.5188.
Kim ST, Lee J, Hong M, Park K, Park JO, Ahn T, Park SH, Park YS, Lim HY, Sun J-M, Ahn JS, Ahn M-J, Kim HC, Sohn TS, Choi DI, Cho JH, Heo JS, Kwon W, Uhm SW, Lee H, Min B-H, Hong SN, Kim DH, Jung SH, Park W, Kim K-M, Kang WK. The NEXT-1 (Next generation pErsonalized tX with mulTi-omics and preclinical model) trial: prospective molecular screening trial of metastatic solid cancer patients, a feasibility analysis. Oncotarget. 2015 Oct 20;6(32):33358–33368.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

October 20, 2015

Volume

6

Issue

32

Start / End Page

33358 / 33368

Location

United States

Related Subject Headings

  • Young Adult
  • Precision Medicine
  • Neoplasms
  • Neoplasm Metastasis
  • Molecular Diagnostic Techniques
  • Middle Aged
  • Male
  • Humans
  • High-Throughput Nucleotide Sequencing
  • Genomics