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Arp2/3 complex function in the epidermis

Publication ,  Journal Article
Lechler, T
Published in: Tissue Barriers
October 30, 2014

An exciting frontier in biology is understanding the functions of basic cell biological machinery in complex tissues. This approach is expected to uncover novel modes of regulation as well as reveal how core machinery is repurposed by different tissues to accomplish different physiological outputs. F-actin plays roles in cell shape, adhesion, migration and signaling – diverse functions that require a specific organization established by a myriad of regulators. Here, we discuss the role of the actin nucleating Arp2/3 complex and the unexpected roles that it plays in a stratified epithelial tissue, the epidermis. While many expected phenotypes such as defects in architecture and cell adhesion were lacking, loss of the Arp2/3 complex activity resulted in epidermal barrier and differentiation defects. This teaches us that, while informative, cell culture approaches are limiting and that studies of the Arp2/3 complex in diverse tissues are expected to yield many more surprises.

Duke Scholars

Published In

Tissue Barriers

DOI

EISSN

2168-8370

ISSN

2168-8362

Publication Date

October 30, 2014

Volume

2

Issue

4
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lechler, T. (2014). Arp2/3 complex function in the epidermis. Tissue Barriers, 2(4). https://doi.org/10.4161/21688362.2014.944445
Lechler, T. “Arp2/3 complex function in the epidermis.” Tissue Barriers 2, no. 4 (October 30, 2014). https://doi.org/10.4161/21688362.2014.944445.
Lechler T. Arp2/3 complex function in the epidermis. Tissue Barriers. 2014 Oct 30;2(4).
Lechler, T. “Arp2/3 complex function in the epidermis.” Tissue Barriers, vol. 2, no. 4, Oct. 2014. Scopus, doi:10.4161/21688362.2014.944445.
Lechler T. Arp2/3 complex function in the epidermis. Tissue Barriers. 2014 Oct 30;2(4).

Published In

Tissue Barriers

DOI

EISSN

2168-8370

ISSN

2168-8362

Publication Date

October 30, 2014

Volume

2

Issue

4